Dopamine is produced in the hypothalamus and regulates the secretion of prolactin from the pituitary gland. The medications for treating hyperprolactinaemia are all dopamine agonists (simulates dopamine receptors). These are all medications used to treat hyperprolactinemia:
- Cabergolin (Cabase, Teva and Dostinex)
- Bromocriptin (Parlodel)
- Quinagolid (Norprolac)
- Pergolide (Permax)
Cabergolin is suspected of causing heart problems and an echocardiogram is recommended to be performed once a year. This unfortunate side effect has been reported in patients with Parkinson’s disease. People with Parkinson’s are treated with much higher doses of Cabergolin. Heart problems have not yet been reported in hyperprolactinemic patients (Great… I guess?).
All of the mentioned drugs can cause side effects but we will all experience the treatment in different ways. Some have no side effects and some are intolerant and must switch medication.
If hyperprolactinemia is caused by a tumor and all medications are not tolerated, surgery might be a last resort. Surgery is not preferred because of very frequent tumor regrowth and possible complications. Radiation is almost never used because it causes more severe side effects than the condition itself. But in a rare case of malign prolactinoma it can be the only option left.
While medicated you cannot donate blood.